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 D89.810 

(ACUTE GRAFT VERSUS HOST DESEASE)

Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen.GVHD usually goes away a year or so after the transplant, when your body starts to make its own white blood cells from the donor cells. But some people have to manage it for many years.Chronic graft-v-host disease (chronic GVHD) is a frequent cause of late morbidity and death after bone marrow transplantation (BMT). The actuarial survival after onset of chronic GVHD in 85 patients was 42% (95%Cl = 29%, 54%) at 10 years.

Acute GVHD disease usually involves a distinct set of clinical symptoms and signs that include dermatitis, or skin inflammation, is characterized by an itchy, red, and possibly painful rash. Some 62% of BMT patients survived at least 365 days, and of those surviving 365 days, 89% survived at least another 365 days. Of the patients who survived 6 years post-BMT, 98.5% survived at least another year. 

Disease recurrence is a devastating event after allogeneic hematopoietic stem cell transplantation as treatment for acute myeloid leukemia (AML). Median time to relapse is approximately 4 months and the majority of relapses occur within 2 years after transplant. The prognosis is usually poor.

In patients with MRD measured after the transplant, the survival rate dropped to 35% leukemia-free and 55% overall. Another study on adult survivors of bone marrow transplant revealed lower patient quality of life when any of the following conditions are present: severe, chronic GVHD. lower performance. it's easier to collect stem cells from the bloodstream than bone marrow. your treatment team can usually collect more cells from the bloodstream. blood counts tend to recover quicker following a stem cell transplant.

• D89.810 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2022 edition of ICD-10-CM D89.810 became effective on October 1, 2021.
• This is the American ICD-10-CM version of D89.810 - other international versions of ICD-10 D89.810 may differ.

The following code(s) above D89.810 contain annotation back-references

 that may be applicable to D89.810:

• D50-D89 
   Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
• D80-D89 
   Certain disorders involving the immune mechanism
• D89 
   Other disorders involving the immune mechanism, not elsewhere classified
• D89.81 
   Graft-versus-host disease

Approximate Synonyms

• Acute graft versus host disease
• Acute graft versus host disease due to kidney transplant
• Acute graft versus host reaction due to bone marrow transplant
• Graft versus host disease due to kidney transplant
• Graft versus host reaction, bone marrow transplant

Clinical Information

• A syndrome of immologically mediated tissue damage occurring following allogeneic transplant usually affecting the skin, liver, and gi tract. Onset is usually within one hundred days of transplantation or immunologic manipulation.

ICD-10-CM D89.810 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):

• 808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
• 809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
• 810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Convert D89.810 to ICD-9-CM

Code History

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change

Diagnosis Index entries containing back-references to D89.810:

• Disease, diseased - see also Syndrome
  • graft-versus-host (GVH) D89.813
    • acute D89.810
  • host-versus-graft D89.813
    • acute D89.810
• Graft-versus-host disease D89.813
  • acute D89.810

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